Lithium Hydroxide → HCID 68293067, compound

Participants

Reaction Steps

1.65 g (4.9 mmol) of methyl 6-chloro-1-cyclopropyl-5-(cyclopropylcarbamoyl)-1H-benzimidazole-2-carboxylate were dissolved in 82 ml of THF and admixed at 0° C. with 0.24 g (9.89 mmol) of lithium hydroxide predissolved in 18 ml of water, and the reaction mixture was stirred at room temperature for 18 hours. The THF was distilled off and the aqueous phase was extracted three times with ethyl acetate; the aqueous phase was adjusted to pH=3 with HCl. The solid which precipitates out was filtered off with suction. Due to its relative instability, the acid was used for subsequent reactions without further purification.

Provenance & Evidence