Ethyl 3-oxo-4-phenylbutanoate → HCID 178510214, compound

HRID 514333Notes

Reaction equation

HRID 514333 reaction equation
[NH:1]([C:3]1[CH:8]=[C:7]([C:9]#[N:10])[CH:6]=[CH:5][N:4]=1)[NH2:2].O=[C:12]([CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH2:13][C:14](OCC)=[O:15]>>[CH2:19]([C:12]1[CH:13]=[C:14]([OH:15])[N:1]([C:3]2[CH:8]=[C:7]([C:9]#[N:10])[CH:6]=[CH:5][N:4]=2)[N:2]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 225855Ethyl 3-oxo-4-phenylbutanoateHCID 201187142-Hydrazinylpyridine-4-carbonitrile

Product 1

HCID 178510214HCID 178510214, compoundYield 53%

Procedure

The title compound was prepared in 53% yield from 2-hydrazinylpyridine-4-carbonitrile (PREPARATION 2) and ethyl 3-oxo-4-phenylbutanoate according to the procedure for the preparation of Example 3, part A. [M+H] Calc'd for C16H12N4O, 277. Found, 277.

Sources & evidence

ORD record
ord-1bd53c8ad02747dd85672b6dacfec08c
Source dataset
uspto-grants-2015_08
Patent number
US09107916B2

Reaction notes

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