HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoroacetophenone → 3-(Dimethylamino)-1-(3-fluorophenyl)prop-2-en-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoroacetophenone | HCID 9967 | — |
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Product | 3-(Dimethylamino)-1-(3-fluorophenyl)prop-2-en-1-one | HCID 5714075 | 92% |
Reaction Steps
The title compound was prepared in 92% yield from 1-(3-fluorophenyl)ethanone and DMF-DMA according to the procedure for the preparation of Example 12, part A. 1H NMR (400 MHz, CDCl3): δ 2.93 (3H, s), 3.15 (3H, s), 5.65 (1H, d, J=12.4 Hz), 7.11-7.16 (1H, m), 7.34-7.39 (1H, m), 7.57-7.67 (2H, m), 7.81 (1H, d, J=12.4 Hz).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09107916B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-4d98ab79dee44c09b527e9e7b52433c2 |
| Source note | uspto-grants-2015_08 |