2-Hydrazinylpyridine-4-carbonitrile hydrochloride salt → HCID 86725493, compound

HRID 514356Notes

Reaction equation

HRID 514356 reaction equation
Cl.[NH:2]([C:4]1[CH:9]=[C:8]([C:10]#[N:11])[CH:7]=[CH:6][N:5]=1)[NH2:3].CN(C)/[CH:14]=[CH:15]/[C:16]([C:18]1[CH:23]=[CH:22][C:21]([S:24]([CH3:27])(=[O:26])=[O:25])=[CH:20][CH:19]=1)=O>>[CH3:27][S:24]([C:21]1[CH:22]=[CH:23][C:18]([C:16]2[N:2]([C:4]3[CH:9]=[C:8]([C:10]#[N:11])[CH:7]=[CH:6][N:5]=3)[N:3]=[CH:14][CH:15]=2)=[CH:19][CH:20]=1)(=[O:25])=[O:26]

Participants

3

Reactant 2

HCID 867254842-Hydrazinylpyridine-4-carbonitrile hydrochloride saltHCID 86725492HCID 86725492, compound

Product 1

HCID 86725493HCID 86725493, compoundYield 100%

Procedure

The title compound was prepared in 100% yield from 2-hydrazinylpyridine-4-carbonitrile hydrochloride salt (PREPARATION 3) and (2E)-3-(dimethylamino)-1-[4-(methylsulfonyl)phenyl]prop-2-en-1-one according to the procedure for the preparation of Example 12, part B. 1H NMR (400 MHz, CDCl3): δ 3.10 (3H, s), 6.58 (1H, d, J=1.6 Hz), 7.39 (1H, dd, J=5.2, 1.2 Hz), 7.51 (2H, d, J=8.4 Hz), 7.81 (1H, d, J=1.6 Hz), 7.93 (2H, d, J=8.4 Hz), 8.20 (1H, s), 8.29 (1H, d, J=5.2 Hz).

Sources & evidence

ORD record
ord-911d6d999a974308acd28a47c3b675ee
Source dataset
uspto-grants-2015_08
Patent number
US09107916B2

Reaction notes

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