4-Hydroxymethylpyridine → HCID 90205196, compound

HRID 514408Notes

Reaction equation

HRID 514408 reaction equation
[OH:1][C:2]1[N:6]([C:7]2[CH:12]=[C:11]([C:13]#[N:14])[CH:10]=[CH:9][N:8]=2)[N:5]=[CH:4][CH:3]=1.[N:15]1[CH:20]=[CH:19][C:18]([CH2:21]O)=[CH:17][CH:16]=1>>[N:15]1[CH:20]=[CH:19][C:18]([CH2:21][O:1][C:2]2[N:6]([C:7]3[CH:12]=[C:11]([C:13]#[N:14])[CH:10]=[CH:9][N:8]=3)[N:5]=[CH:4][CH:3]=2)=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 114724-HydroxymethylpyridineHCID 178510213HCID 178510213, compound

Product 1

HCID 90205196HCID 90205196, compound

Procedure

The title compound was prepared from 2-(5-hydroxy-1H-pyrazol-1-yl)pyridine-4-carbonitrile and pyridin-4-ylmethanol according to the procedure for the preparation of Example 39, part C. 1H NMR (400 MHz, CDCl3): δ 5.29 (2H, d, J=9.2 Hz), 5.72 (1H, d, J=2.0 Hz), 7.38 (2H, d, J=6.4 Hz), 7.44 (1H, dd, J=1.6 Hz, J=5.2 Hz), 7.57 (1H, d, J=2.0 Hz), 8.09 (1H, s), 8.65 (2H, d, J=5.2 Hz), 8.72 (1H, d, J=5.2 Hz). [M+H] Calc'd for C15H11N5O, 278. Found, 278.

Sources & evidence

ORD record
ord-4ec7870621244acbba75548c2a2df332
Source dataset
uspto-grants-2015_08
Patent number
US09107916B2

Reaction notes

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