(3,3-Difluorocyclobutyl)methanol → HCID 86725543, compound

HRID 514418Notes

Reaction equation

HRID 514418 reaction equation
[OH:1][C:2]1[N:6]([C:7]2[CH:12]=[C:11]([C:13]#[N:14])[CH:10]=[CH:9][N:8]=2)[N:5]=[CH:4][CH:3]=1.[F:15][C:16]1([F:22])[CH2:19][CH:18]([CH2:20]O)[CH2:17]1>>[F:15][C:16]1([F:22])[CH2:19][CH:18]([CH2:20][O:1][C:2]2[N:6]([C:7]3[CH:12]=[C:11]([C:13]#[N:14])[CH:10]=[CH:9][N:8]=3)[N:5]=[CH:4][CH:3]=2)[CH2:17]1

Participants

3

Reactant 2

HCID 45480377(3,3-Difluorocyclobutyl)methanolHCID 178510213HCID 178510213, compound

Product 1

HCID 86725543HCID 86725543, compound

Procedure

The title compound was prepared from 2-(5-hydroxy-1H-pyrazol-1-yl)pyridine-4-carbonitrile and (3,3-difluorocyclobutyl)methanol according to the procedure for the preparation of Example 39, part C. 1H NMR (400 MHz, CDCl3): δ 2.48-2.71 (5H, m), 5.14 (2H, d, J=4.4 Hz), 5.64 (1H, d, J=1.6 Hz), 7.34 (1H, dd, J=0.4 Hz, J=4.8 Hz), 7.51 (1H, d, J=2.0 Hz), 7.93 (1H, s), 8.61 (1H, d, J=4.8 Hz). [M+H] Calc'd for C14H12F2N4O, 291. Found, 291.

Sources & evidence

ORD record
ord-6dbc39e92e8047f6bfca22686b5171b9
Source dataset
uspto-grants-2015_08
Patent number
US09107916B2

Reaction notes

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