3-(Hydroxymethyl)benzonitrile → Methyl 2-[5-[(3-cyanophenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylate

HRID 514444Notes

Reaction equation

HRID 514444 reaction equation
[OH:1][C:2]1[N:6]([C:7]2[CH:12]=[C:11]([C:13]([O:15][CH3:16])=[O:14])[CH:10]=[CH:9][N:8]=2)[N:5]=[CH:4][CH:3]=1.[C:17]([C:19]1[CH:20]=[C:21]([CH2:25]O)[CH:22]=[CH:23][CH:24]=1)#[N:18]>>[C:17]([C:19]1[CH:20]=[C:21]([CH2:25][O:1][C:2]2[N:6]([C:7]3[CH:12]=[C:11]([C:13]([O:15][CH3:16])=[O:14])[CH:10]=[CH:9][N:8]=3)[N:5]=[CH:4][CH:3]=2)[CH:22]=[CH:23][CH:24]=1)#[N:18]

Participants

3

Reactant 2

HCID 27346773-(Hydroxymethyl)benzonitrileHCID 178498428HCID 178498428, compound

Product 1

HCID 86725565Methyl 2-[5-[(3-cyanophenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylate

Procedure

The title compound was prepared from methyl 2-(5-hydroxypyrazol-1-yl)pyridine-4-carboxylate (PREPARATION 6) and (3-cyanophenyl)methanol according to the procedure for the preparation of Example 39, part C. [M+H] Calc'd for C18H14N4O3, 335. Found, 335.

Sources & evidence

ORD record
ord-13d0ec531da145a6a5bfe740157f7104
Source dataset
uspto-grants-2015_08
Patent number
US09107916B2

Reaction notes

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