1-Bromo-2-methylpropane → HCID 86725596, compound

HRID 514475Notes

Reaction equation

HRID 514475 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:9][OH:10])=[C:6]([OH:8])[CH:7]=1.Br[CH2:12][CH:13]([CH3:15])[CH3:14]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:9][OH:10])=[C:6]([O:8][CH2:12][CH:13]([CH3:15])[CH3:14])[CH:7]=1

Participants

3

Reactant 2

HCID 65551-Bromo-2-methylpropaneHCID 3271485-Chloro-2-(hydroxymethyl)phenol

Product 1

HCID 86725596HCID 86725596, compound

Procedure

The title compound was prepared from 5-chloro-2-(hydroxymethyl)phenol (PREPARATION 7) and 1-bromo-2-methylpropane according to the procedure for the preparation of Example 111, part A. 1H NMR (400 MHz, CDCl3): δ 1.04 (6H, d, J=6.8 Hz), 2.07-2.17 (1H, m), 2.29 (1H, s), 3.75 (2H, d, J=6.4 Hz), 4.65 (2H, d, J=4.8 Hz), 6.83 (1H, d, J=2.0 Hz), 6.90 (1H, dd, J=2.0 Hz, 8.0 Hz), 7.20 (1H, d, J=8.0 Hz).

Sources & evidence

ORD record
ord-745418a2525245cfbb65cf2524321d38
Source dataset
uspto-grants-2015_08
Patent number
US09107916B2

Reaction notes

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