反应详情

Subsequently, the obtained 5-(t-butyldimethylsiloxymethyl)-2,2-dimethyl-5-[(2-nitro-1H-imidazol-1-yl)methyl]-1,3-dioxane is reacted with tetra-n-butylammonium fluoride in an organic solvent by for example a method of E. J. Corey et al. (Journal of American Chemical Society, 1972, 94, p. 6190) and purified, to give 2,2-dimethyl-5-hydroxymethyl-5-[(2-nitro-1H-imidazol-1-yl)methyl]-1,3-dioxane (FIG. 1, Step 4).

1. customCorey et al. (Journal of American Chemical Society, 1972, 94, p. 6190) and purified