反应详情

温度

80 °C

56.3 mg (0.206 mmol equivalents) of 2,2-dimethyl-5-fluoromethyl-5-[(2-nitro-1H-imidazol-1-yl)methyl]-1,3-dioxane was dissolved in 2 mL of methanol, 2 mL of 1 mol/L hydrochloric acid was added thereto, and the mixture was heated at 80° C. for 2 hours. After completion of the reaction, the reaction liquid was cooled to room temperature (25° C.), the solvent was then removed by distillation, and the obtained crude product was washed with ethyl acetate to give 47.3 mg (0.203 mmol equivalents) of 1-(2,2-dihydroxymethyl-3-fluoropropyl)-2-nitroimidazole (FIG. 2, Step 2).

1. customAfter completion of the reaction
2. customthe reaction liquid
3. temperaturewas cooled to room temperature (25° C.)
4. customthe solvent was then removed by distillation
5. customthe obtained crude product
6. washwas washed with ethyl acetate