Methyl iodide → HCID 117951634, compound

Participants

Reaction Steps

Referring to Scheme 4 below, N-(3-methylcyclohexyl)pyrrolidine prepared in Example 2 above was quaternized with methyl iodide in a similar fashion to the procedure described in in example 3. The quaternization afforded the desired N-methyl-N-(3-methylcyclohexyl)pyrrolidinium iodide in 94% yield. The resulting iodide salt was exchanged with Bio-Rad AG 1-X8 ion-exchange resin as described in example 3 to give N-methyl-N-(3-methylcyclohexyl)pyrrolidinium hydroxide in 98% yield (titration analysis).

Provenance & Evidence