Iodoethane → HCID 117951629, compound

Participants

Reaction Steps

As shown in Scheme 5, N-(3-methylcyclohexyl)pyrrolidine prepared in Example 2 above was quaternized with ethyl iodide in a similar fashion to the procedure described in example 5 with the exception of using ethyl iodide in place of methyl iodide. The quaternization afforded the desired N-ethyl-N-(3-methylcyclohexyl)pyrrolidinium iodide in 85% yield. The resulting N-ethyl-N-(3-methylcyclohexyl)pyrrolidinium iodide salt was exchanged with Bio-Rad AG 1-X8 ion-exchange resin as described in example 3 to give N-methyl-N-(3-methylcyclohexyl)pyrrolidinium hydroxide in 88% yield (by titration).

Provenance & Evidence