HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[(2-Methylpropane-2-sulfonyl)methyl]aniline → 4-[2-(Benzyloxy)-4-fluorophenyl]-N-{3-[(tert-butylsulfonyl)methyl]phenyl}-5-fluoropyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[(2-Methylpropane-2-sulfonyl)methyl]aniline | HCID 43444396 | — |
| Reactant | 4-[2-(Benzyloxy)-4-fluorophenyl]-2-chloro-5-fluoropyrimidine | HCID 86729610 | — |
| Product | 4-[2-(Benzyloxy)-4-fluorophenyl]-N-{3-[(tert-butylsulfonyl)methyl]phenyl}-5-fluoropyrimidin-2-amine | HCID 71511133 | — |
Reaction Steps
Example 4 was prepared under similar conditions as described in the preparation of Example 3 using 4-[2-(benzyloxy)-4-fluorophenyl]-2-chloro-5-fluoropyrimidine and 3-[(tert-butylsulfonyl)methyl]aniline (UkrOrgSynthesis Ltd.). The batch was purified by preparative HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09108926B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-e74b9b0f549f40edb0d5a69bdbeb3837 |
| Source note | uspto-grants-2015_08 |