HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[(Propane-2-sulfonyl)methyl]aniline → 4-[2-(Benzyloxy)-4-fluorophenyl]-5-fluoro-N-{3-[(propan-2-ylsulfonyl)methyl]phenyl}pyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[(Propane-2-sulfonyl)methyl]aniline | HCID 22501935 | — |
| Reactant | 4-[2-(Benzyloxy)-4-fluorophenyl]-2-chloro-5-fluoropyrimidine | HCID 86729610 | — |
| Product | 4-[2-(Benzyloxy)-4-fluorophenyl]-5-fluoro-N-{3-[(propan-2-ylsulfonyl)methyl]phenyl}pyrimidin-2-amine | HCID 71511134 | — |
Reaction Steps
Example 5 was prepared under similar conditions as described in the preparation of Example 3 using 4-[2-(benzyloxy)-4-fluorophenyl]-2-chloro-5-fluoropyrimidine and 3-[(propan-2-ylsulfonyl)methyl]aniline (UkrOrgSynthesis Ltd.). The batch was purified by preparative HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09108926B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-9ff185a70c6445c89d3e6e5629899c7e |
| Source note | uspto-grants-2015_08 |