HRID514700

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID51889996

未命名化合物

结构：Fc1ccc(-c2nc(Cl)ncc2F)c(OCc2ccccc2)c1

HCID86729610

未命名化合物

PRODUCTS

生成物

结构：O=S(=O)(Cc1cccc(Nc2ncc(F)c(-c3ccc(F)cc3OCc3ccccc3)n2)c1)C1CCCCC1

HCID71511135

未命名化合物

PROCEDURE

实验过程

Example 6 was prepared under similar conditions as described in the preparation of Example 3 using 4-[2-(benzyloxy)-4-fluorophenyl]-2-chloro-5-fluoropyrimidine and 3-[(cyclohexylsulfonyl)methyl]aniline (UkrOrgSynthesis Ltd.). The batch was purified by preparative HPLC.

WORKUP

后处理

customExample 6 was prepared under similar conditions
customThe batch was purified by preparative HPLC

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f9a9bcc2b73f4794b8acc8a81190c2cf
来源数据集: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09108926B2
来源说明: uspto-grants-2015_08

反应 SMILES

[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[C:16]1[C:21]([F:22])=[CH:20][N:19]=[C:18](Cl)[N:17]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:24]1([S:30]([CH2:33][C:34]2[CH:35]=[C:36]([CH:38]=[CH:39][CH:40]=2)[NH2:37])(=[O:32])=[O:31])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1>>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[C:16]1[C:21]([F:22])=[CH:20][N:19]=[C:18]([NH:37][C:36]2[CH:38]=[CH:39][CH:40]=[C:34]([CH2:33][S:30]([CH:24]3[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]3)(=[O:32])=[O:31])[CH:35]=2)[N:17]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1