Benzene, 1-(bromomethyl)-3-nitro- → 1-[(Cyclopropylsulfonyl)methyl]-3-nitrobenzene

Participants

Reaction Conditions

Reaction Steps

Sodium cyclopropanesulfinate (1.04 g; 8.1 mmol) was added to a solution of 1-(bromomethyl)-3-nitrobenzene (1.17 g; 5.4 mmol) in acetonitrile (50 mL) at room temperature. The batch was stirred at 90° C. for 4 hours. After cooling, the batch was diluted with water and extracted with DCM (2×). The combined organic phases were filtered using a Whatman filter and concentrated to give the desired product (1.26 g; 5.2 mmol) that was used without further purifications.

Provenance & Evidence