HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidine → 5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{3-fluoro-5-[(methylsulfonyl)methyl]phenyl}pyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidine | HCID 86729609 | — |
| Reactant | 3-Fluoro-5-[(methylsulfonyl)methyl]aniline | HCID 86729614 | — |
| Product | 5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{3-fluoro-5-[(methylsulfonyl)methyl]phenyl}pyrimidin-2-amine | HCID 71509033 | — |
Reaction Steps
Example 12 was prepared under similar conditions as described in the preparation of Example 1 using 2-chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidine and 3-fluoro-5-[(methylsulfonyl)methyl]aniline. The batch was purified by preparative HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09108926B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-a8bec637a0b84c20a81f3f4ed683eb12 |
| Source note | uspto-grants-2015_08 |