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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 514711Generated: October 30, 2026

3-(Methanesulfonylmethyl)aniline → 4-(2,4-difluorophenyl)-5-fluoro-N-{3-[(methylsulfonyl)methyl]phenyl}pyrimidin-2-amine

https://huagongshe.com/reaction/514711

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Methanesulfonylmethyl)anilineHCID 21956339—
Reactant2-Chloro-4-(2,4-difluorophenyl)-5-fluoropyrimidineHCID 79073071—
Product4-(2,4-difluorophenyl)-5-fluoro-N-{3-[(methylsulfonyl)methyl]phenyl}pyrimidin-2-amineHCID 86729615—

Reaction Steps

Example 16.2 was prepared under similar conditions as described in the preparation of Example 3. using 2-chloro-4-(2,4-difluorophenyl)-5-fluoropyrimidine (Intermediate 16.1) and 3-[(methylsulfonyl)methyl]aniline (Intermediate 1.3). The batch was purified by preparative HPLC.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09108926B2
Source datasetuspto-grants-2015_08
ORD IDord-d8bf1520036c4461bbe5e39d68831b87
Source noteuspto-grants-2015_08