HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluorobenzylic alcohol → 5-Fluoro-4-{2-fluoro-4-[(3-fluorobenzyl)oxy]phenyl}-N-{3-[(methylsulfonyl)methyl]phenyl}pyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluorobenzylic alcohol | HCID 68008 | — |
| Reactant | 4-(2,4-difluorophenyl)-5-fluoro-N-{3-[(methylsulfonyl)methyl]phenyl}pyrimidin-2-amine | HCID 86729615 | — |
| Product | 5-Fluoro-4-{2-fluoro-4-[(3-fluorobenzyl)oxy]phenyl}-N-{3-[(methylsulfonyl)methyl]phenyl}pyrimidin-2-amine | HCID 86729617 | — |
Reaction Steps
Example 18 was prepared under similar conditions as described in the preparation of Example 16 using 4-(2,4-difluorophenyl)-5-fluoro-N-{3-[(methylsulfonyl)methyl]phenyl}pyrimidin-2-amine (Intermediate 16.2) and (3-fluorophenyl)methanol (ABCR GmbH & CO. KG). The batch was purified by preparative HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09108926B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-b6c556e06ded414b9307732a583bb629 |
| Source note | uspto-grants-2015_08 |