反应详情

A solution of compound 37 (0.84 g, 2.51 mmol) in PhNO2 (20 mL) was cooled in an ice bath. Then AlCl3 (1.7 g, 12.7 mmol, 5 eq.) and after that, AcCl (0.9 mL, 12.7 mmol, 5 eq.) were added. The mixture was kept for 40 min (LC/MS monitoring), diluted with water, neutralized with Na2CO3, extracted with CHCl3, and evaporated. The product was purified on a short thick column, eluent: CHCl3-MeOH 99:1→90:10. Yield of 38: 0.658 g (69%).

1. extractionextracted with CHCl3
2. customevaporated
3. customThe product was purified on a short thick column, eluent