Trifluoroacetic acid → 4((2,2-Difluorocyclopropyl)methy)piperidin-4-ol

Participants

Reaction Steps

To a solution of compound 11C (1 eq.) in DCM, was added TFA (10 eq.), the reaction mixture was stirred at room temperature for about 2 hours, when TLC detected no s.m. The reaction mixture was concentrated to afford the desired product 11D. The crude product was used for the next step directly without further purification. LC-MS: m/z 192.3 (M+H)+

Provenance & Evidence