反应详情

温度

60 °C

To a mixture of 6-fluoro-8-nitroquinoline (1.6 g, 8.3 mmol), and NH4Cl (2 g, 41.5 mmol) in EtOH/H2O (10 mL/10 mL) in a round bottom flask equipped with a refluxing condenser was added Zn (5.4 g, 16.6 mmol) dust in portions at room temperature, and the resulting mixture was stirred at 60° C. overnight. The reaction mixture was filtered, and the filtrate was extracted with EtOAc. The combined organic layers were dried over Na2SO4, and concentrated to give 1.0 g of crude product, which was used directly for the next step without further purification. LC-MS: m/z 163.2 (M+H)+

1. customequipped with a refluxing condenser
2. filtrationThe reaction mixture was filtered
3. extractionthe filtrate was extracted with EtOAc
4. dry with materialThe combined organic layers were dried over Na2SO4
5. concentrationconcentrated