(E)-tert-butyl 4-hydroxy-4-(4,4,4-trifluorobut-1-enyl)piperidine-1-carboxylate → (E)-4-(4,4,4-trifluorobut-1-enyl)piperidin-4-ol

HRID 514868Notes

Reaction equation

HRID 514868 reaction equation
[OH:1][C:2]1(/[CH:15]=[CH:16]/[CH2:17][C:18]([F:21])([F:20])[F:19])[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4][CH2:3]1>Cl.O1CCOCC1>[F:21][C:18]([F:19])([F:20])[CH2:17]/[CH:16]=[CH:15]/[C:2]1([OH:1])[CH2:3][CH2:4][NH:5][CH2:6][CH2:7]1

Participants

3

Reactant 1

HCID 90447581(E)-tert-butyl 4-hydroxy-4-(4,4,4-trifluorobut-1-enyl)piperidine-1-carboxylate

Product 1

HCID 90447571(E)-4-(4,4,4-trifluorobut-1-enyl)piperidin-4-ol

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

A solution of (E)-tert-butyl 4-hydroxy-4-(4,4,4-trifluorobut-1-enyl)piperidine-1-carboxylate (200 mg, 0.65 mmol) in 3M HCl/1,4-dioxane (5 mL) was stirred at room temperature for 2 hours. The solution was evaporated to dryness under reduced pressure to give the product which was used in the next step without further purification. LC-MS: m/z 210.2 (M+H)+.

Workup

  1. customThe solution was evaporated to dryness under reduced pressure
  2. customto give the product which
  3. customwas used in the next step without further purification

Sources & evidence

ORD record
ord-33ba42fdad64425a9ae9196f52730cc5
Source dataset
uspto-grants-2015_08
Patent number
US09108921B2

Reaction notes

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