HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(3,3-Difluoro-2-methylpropyl)piperidin-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 4-((benzyloxy)methoxy)-4-(3,3-difluoro-2-methylpropyl)piperidine-1-carboxylate | HCID 90418894 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(3,3-Difluoro-2-methylpropyl)piperidin-4-ol | HCID 90419016 | 71.3% |
Reaction Steps
A mixture of tert-butyl 4-((benzyloxy)methoxy)-4-(3,3-difluoro-2-methylpropyl)piperidine-1-carboxylate (0.33 g) and 5 M HCl in MeOH (4 mL) was stirred in methanol (15 mL) for 3 hrs. The solvent was then removed under vacuum to obtain crude product (4-(3,3-difluoro-2-methylpropyl)piperidin-4-ol (0.11 g). LC-MS: m/z 194.2 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09108921B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-c2916dbb34ca4c04840691291093484a |
| Source note | uspto-grants-2015_08 |