Dichloromethane → HCID 70664378, compound

Participants

Reaction Steps

To a dichloromethane (100 mL)/diethyl ether (200 mL) solution of (S)-pyrrolidin-3-ol (9.80 mL, 121 mmol) and triethylamine (21.9 mL, 157 mmol) at 0° C. was added tert-butyl isocyanate (13.8 mL, 121 mmol). The reaction mixture was stirred for 30 minutes and concentrated in vacuo to afford the title compound. 1H NMR (500 MHz, CDCl3) δ 4.54-4.38 (m, 1H), 4.10 (br s, 1H), 3.48-3.32 (m, 5H), 2.06-1.95 (m, 2H), 1.35 (s, 9H); LC-MS: m/z 187.3 (M+H).

Provenance & Evidence