Morpholine → HCID 22736255, compound

HRID 51490Notes

Reaction equation

HRID 51490 reaction equation
[NH2:1][C:2]1[C:3]2[C:10]([C:11]3[CH:25]=[CH:24][C:14]([O:15][C:16]4[CH:23]=[CH:22][C:19]([CH:20]=O)=[CH:18][CH:17]=4)=[CH:13][CH:12]=3)=[CH:9][N:8]([CH:26]3[CH2:30][CH2:29][O:28][CH2:27]3)[C:4]=2[N:5]=[CH:6][N:7]=1.[NH:31]1[CH2:36][CH2:35][O:34][CH2:33][CH2:32]1>>[O:34]1[CH2:35][CH2:36][N:31]([CH2:20][C:19]2[CH:22]=[CH:23][C:16]([O:15][C:14]3[CH:13]=[CH:12][C:11]([C:10]4[C:3]5[C:2]([NH2:1])=[N:7][CH:6]=[N:5][C:4]=5[N:8]([CH:26]5[CH2:30][CH2:29][O:28][CH2:27]5)[CH:9]=4)=[CH:25][CH:24]=3)=[CH:17][CH:18]=2)[CH2:32][CH2:33]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 227362404-[4-(4-amino-7-(3-tetrahydrofuryl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenoxy]benzaldehyde

Product 1

HCID 22736255HCID 22736255, compound

Procedure

In a similar manner to Example 10 a mixture of 4-[4-(4-amino-7-(3-tetrahydrofuryl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenoxy]benzaldehyde (336 mg), and morpholine (146 mg) were reacted to give 5-[4-(4-morpholinomethylphenoxy)-phenyl]-7-(3-tetrahydrofuryl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine, m.p 142-144° C.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-ce56459a6fe84d028139789bf8cd79b8
Source dataset
uspto-grants-2004_03
Patent number
US06713474B2

Reaction notes

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