反应详情

温度

0 °C

4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine (1.0 g) was added to a mixture of sodium hydride (0.158 g of a 60% dispersion in mineral oil) in dimethyl formamide (70 ml) with stirring under nitrogen at 0° C. The mixture was stirred at 0° C. for 1 hour and then α-bromo-γ-butyrolactone (0.60 g) in dimethylformamide (6 ml) was added dropwise with stirring at 0° C. The mixture was stirred at ambient temperature for 18 hours and then quenched with water (100 ml). The mixture was extracted with ethyl acetate. The combined extracts were dried and evaporated to give 2-[4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-butyrolactone as an oil which was used directly in b).

1. stirringThe mixture was stirred at 0° C. for 1 hour
2. stirringwith stirring at 0° C
3. stirringThe mixture was stirred at ambient temperature for 18 hours
4. customquenched with water (100 ml)
5. extractionThe mixture was extracted with ethyl acetate
6. customThe combined extracts were dried
7. customevaporated