1,1'-Thiocarbonyldiimidazole → HCID 59550995, compound

HRID 514980Notes

Reaction equation

HRID 514980 reaction equation
[CH:1]([N:4]1[C:12]2[C:7](=[C:8]([NH2:15])[CH:9]=[CH:10][C:11]=2[O:13][CH3:14])[CH:6]=[CH:5]1)([CH3:3])[CH3:2].[C:16](N1C=CN=C1)(N1C=CN=C1)=[S:17]>ClCCl>[CH:1]([N:4]1[C:12]2[C:7](=[C:8]([N:15]=[C:16]=[S:17])[CH:9]=[CH:10][C:11]=2[O:13][CH3:14])[CH:6]=[CH:5]1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 802641,1'-ThiocarbonyldiimidazoleHCID 59551030HCID 59551030, compound

Product 1

HCID 59550995HCID 59550995, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 1-isopropyl-7-methoxy-1H-indol-4-ylamine (U) (1 eq) in dichloromethane was added 1,1′-thiocarbonyldiimidazole (1.2 eq). The reaction was stirred for 2 hrs at room temperature then evaporated to dryness. Further purification by column chromatography produced the pure desired product.

Workup

  1. customthen evaporated to dryness
  2. customFurther purification by column chromatography

Sources & evidence

ORD record
ord-52b5672abcbf493aa65de51fa0129895
Source dataset
uspto-grants-2015_08
Patent number
US09108933B2

Reaction notes

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