Hexane → 1-Bromo-4-[(1S,2R)-2-vinylcyclopropyl]benzene

HRID 515056Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:10][C@@H:9]2[CH:11]=O)=[CH:4][CH:3]=1.[CH3:13]CCCCC>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:10][C@@H:9]2[CH:11]=[CH2:13])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 8058Hexane

HCID 57515374trans-2-(4-Bromophenyl)cyclopropane-1-carbaldehyde

Product 1

HCID 684062521-Bromo-4-[(1S,2R)-2-vinylcyclopropyl]benzene

Procedure

The product from Example 30A was subjected to the conditions outlined in Example 26E, followed by chromatography (100% hexane) to provide the title compound.

Sources & evidence

ORD record: ord-85edee218a884bd4a181099d0089ca25
Source dataset: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09108948B2

Reaction notes

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