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HRID515120

反应详情

EQUATION

反应方程式

HRID 515120 的结构方程式

REACTANTS

反应物

2
结构：Cc1c([C@@H]2CO2)ccc2c1COC2=O
HCID59568646

4-Methyl-5-[(2R)-oxiran-2-yl]-2-benzofuran-1(3H)-one

C11H10O3

2 次

结构：Cc1c([C@@H](O)CN2CCCC(C)(CN)C2)ccc2c1COC2=O.Cl
HCID90409939

未命名化合物

2 次

PRODUCTS

生成物

1
结构：Cc1c([C@@H](O)CNCC2(C)CCCN(C[C@H](O)c3ccc4c(c3C)COC4=O)C2)ccc2c1COC2=O
HCID71565787

未命名化合物

PROCEDURE

实验过程

5-{(1R)-1-Hydroxy-2-[3-({[(2R)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]amino}methyl)-3-methylpiperidin-1-yl]ethyl}-4-methyl-2-benzofuran-1(3H)-one was prepared in a similar fashion to that described for the synthesis of EXAMPLE 1 starting from 5-[(R)-2-[3-(aminomethyl)-3-methylpiperidin-1-yl]-1-hydroxyethyl]-4-methyl-2-benzofuran1(3H)-one hydrochloride [INTERMEDIATE 8] and 4-methyl-5-[(2R)-oxiran-2-yl]-2-benzofuran-1 (3H)-one [INTERMEDIATE 2B].