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HRID515121

反应详情

EQUATION

反应方程式

HRID 515121 的结构方程式

REACTANTS

反应物

2
结构：Cc1c([C@@H]2CO2)ccc2c1COC2=O
HCID59568646

4-Methyl-5-[(2R)-oxiran-2-yl]-2-benzofuran-1(3H)-one

C11H10O3

2 次

结构：Cl.N#Cc1ccc(C(O)CN2CC[C@@H](N)C2)nc1
HCID90410632

未命名化合物

2 次

PRODUCTS

生成物

1
结构：Cc1c([C@@H](O)CN[C@@H]2CCN(CC(O)c3ccc(C#N)cn3)C2)ccc2c1COC2=O
HCID71565791

未命名化合物

PROCEDURE

实验过程

6-(1-Hydroxy-2-((R)-3-((R)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydroisobenzofuran-5-yl)ethylamino)pyrrolidin-1-yl)ethyl)nicotinonitrile was prepared in a similar fashion to that described for the synthesis of EXAMPLE 1 starting from 6-{2-[(3R)-3-aminopyrrolidin-1-yl]-1-hydroxyethyl}pyridine-3-carbonitrile hydrochloride [INTERMEDIATE 11] and 4-methyl-5-[(2R)-oxiran-2-yl]-2-benzofuran-1(3H)-one [INTERMEDIATE 2B].