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HRID515123

反应详情

EQUATION

反应方程式

HRID 515123 的结构方程式

REACTANTS

反应物

2
结构：N#Cc1ccc(S(=O)(=O)Cl)cc1
HCID39497

p-Cyanobenzenesulphonyl chloride

C7H4ClNO2S

结构：Cc1c([C@@H](O)CN2CC[C@@H](N)C2)ccc2c1COC2=O.Cl
HCID90190303

未命名化合物

2 次

PRODUCTS

生成物

1
结构：Cc1c([C@@H](O)CN2CC[C@@H](NS(=O)(=O)c3ccc(C#N)cc3)C2)ccc2c1COC2=O
HCID71565862

未命名化合物

PROCEDURE

实验过程

4-Cyano-N—((R)-1-((R)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydroisobenzofuran-5-yl)ethyl)pyrrolidin-3-yl)benzenesulfonamide was prepared in a similar fashion to that described for the synthesis of EXAMPLE 14 starting from 5-{(1R)-2-[(3R)-3-Aminopyrrolidin-1-yl]-1-hydroxyethyl}-4-methyl-2-benzofuran-1(3H)-one hydrochloride [INTERMEDIATE 4] and 4-cyanobenzene-1-sulfonyl chloride.