4-(1H-1,2,3,4-tetrazol-1-yl)benzene-1-sulfonyl chloride → N-((1-((R)-2-Hydroxy-2-(4-methyl-1-oxo-1,3-dihydroisobenzofuran-5-yl)ethyl)pyrrolidin-2-yl)methyl)-4-(1H-tetrazol-1-yl)benzenesulfonamide

Participants

Reaction Steps

N-((1-((R)-2-Hydroxy-2-(4-methyl-1-oxo-1,3-dihydroisobenzofuran-5-yl)ethyl)pyrrolidin-2-yl)methyl)-4-(1H-tetrazol-1-yl)benzenesulfonamide was prepared in a similar fashion to that described for the synthesis of EXAMPLE 13 starting from 5-41R)-2-(2-(aminomethyl)pyrrolidin-1-yl)-1-hydroxyethyl)-4-methylisobenzofuran-1(3H)-one hydrochloride [INTERMEDIATE 3] and commercially available 4-(1H-tetrazol-1-yl)benzene-1-sulfonyl chloride.

Provenance & Evidence