HRID515127

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID5152094

2-Chloro-5-cyanopyridine

C6H3ClN2

结构：Cc1c([C@@H](O)CN2CCC(C)(CN)C2)ccc2c1COC2=O.Cl

HCID90190541

未命名化合物

2 次

PRODUCTS

生成物

结构：Cc1c([C@@H](O)CN2CCC(CNc3ccc(C#N)cn3)(c3ccccc3)C2)ccc2c1COC2=O

HCID71565945

未命名化合物

PROCEDURE

实验过程

6-((1-((R)-2-Hydroxy-2-(4-methyl-1-oxo-1,3-dihydroisobenzofuran-5-yl)ethyl)-3-phenylpyrrolidin-3-yl)methylamino)nicotinonitrile was prepared in a similar fashion to that described for the synthesis of EXAMPLE 18 starting from 5-[(R)-2-[3-(Aminomethyl)-3-methylpyrrolidin-1-yl]-1-hydroxyethyl}-4-methyl-2-benzofuran-1(3H)-one hydrochloride [INTERMEDIATE 7] and 6-chloropyridine-3-carbonitrile.