反应详情

A solution of 2-ethylsulfanyl-6-methyl-4-morpholin-4-yl-benzonitrile (0.30 g, 1.14 mmol) in concentrated sulfuric acid (15 ml) is stirred at 100° C. for 4 h. After completion of the reaction (monitored by TLC), the reaction mixture is diluted with water (30 ml), basified with aqueous ammonia, and extracted with ethyl acetate (3×15 ml). The organic layer is washed with water (20 ml), brine (15 ml), dried over anhydrous sodium sulfate and evaporated to get 2-ethylsulfanyl-6-methyl-4-morpholin-4-yl-benzamide, which is used in the next step without further purification (0.26 g, 0.92 mmol, 81%).

1. customAfter completion of the reaction (monitored by TLC)
2. extractionextracted with ethyl acetate (3×15 ml)
3. washThe organic layer is washed with water (20 ml), brine (15 ml)
4. dry with materialdried over anhydrous sodium sulfate
5. customevaporated