2,6-Di-tert-butyl-4-methylphenol → HCID 86699735, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of trifluoro-methanesulfonic acid [2-[(4-chlorophenyl)-methyl-carbamoyl]-3-methyl-5-morpholin-4-yl-phenyl]ester (0.20 g, 0.4 mmol) in dioxane (10 ml) are added 2,6-di-tert-butyl-4-methylphenol (few crystals), lithium chloride (0.052 g, 1.22 mmol) and tributylvinyl tin (0.13 ml, 0.45 mmol). The mixture is degassed and flushed with argon for 30 min followed by the addition of tetrakis(triphenylphosphin)palladium(0) (0.01 g, 0.008 mmol). The resulting mixture is heated at 110° C. for 16 h. The reaction mixture is concentrated, diluted with water (10 ml) and extracted with ethyl acetate (3×30 ml). The organic layer is washed with water (20 ml), saturated potassium fluoride solution (2×20 ml), brine (20 ml) and dried over anhydrous sodium sulfate. Evaporation under vacuum afforded the crude product, which is purified by column chromatography (silica gel-10% KF, 30% ethyl acetate/hexane) to yield N-[(4-chlorophenyl)-methyl]-2-methyl-4-morpholin-4-yl-6-vinyl-benzamide (0.12 g, 0.32 mmol, 79%).

Provenance & Evidence