HCID 86699735, compound → HCID 72187886, compound

Participants

Reaction Steps

A solution of N-[(4-chlorophenyl)-methyl]-2-methyl-4-morpholin-4-yl-6-vinyl-benzamide (0.18 g, 0.48 mmol) in ethyl acetate is degassed and flushed with argon for 10 min followed by the addition of Pearlman's catalyst (20% Pd(OH)2/C, 0.08 g). The resulting mixture is stirred under an atmosphere of hydrogen for 2 h. After completion of reaction (monitored by NMR), the reaction mixture is filtered through a pad of celite. The filtrate is concentrated and the residue is purified by preparative HPLC affording N-[(4-chlorophenyl)-methyl]-2-ethyl-6-methyl-4-morpholin-4-yl-benzamide (example 12) (0.105 g, 0.28 mmol, 59%). [M+H]+ 373.2.

Provenance & Evidence