反应详情

To a solution of 2-methoxy-6-methyl-4-morpholin-4-yl-benzoic acid ethyl ester (7.0 g, 25.1 mmol) in dichloromethane (370 ml) is added neat boron tribromide (5.94 ml, 62.7 mmol) at −78° C. The temperature is slowly raised to room temperature over a period of 30 min and stirred for 1 h at room temperature. The reaction mixture is poured onto cold water, extracted with dichloromethane (3×30 ml). Combined organic layers are washed with brine (30 ml), dried over sodium sulfate and evaporated to dryness. The crude material is used in the next step without further purification.

1. extractionextracted with dichloromethane (3×30 ml)
2. washCombined organic layers are washed with brine (30 ml)
3. dry with materialdried over sodium sulfate
4. customevaporated to dryness
5. customThe crude material is used in the next step without further purification