1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 72188014, compound

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Reaction Steps

To a stirred solution of 2-cyclopropyl-6-methyl-4-morpholin-4-yl-benzoic acid (synthesized according to the methods described in sections a) to f)) (0.34 g, 1.3 mmol) in dichloromethane (10 ml) are added 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (0.30 g, 1.56 mmol), hydroxybenzotriazole (0.21 g, 1.56 mmol) and diisopropylethylamine (0.65 ml, 3.9 mmol) at 0° C. and stirred for 15 min before the addition of (3R)-1-amino-4,4-dimethyl-pentan-3-ol (synthesized according to the methods described in sections g) to k)) (0.28 g, 1.69 mmol). The resulting mixture is stirred at room temperature for 16 h. Water (20 ml) is added to the mixture and extracted with dichloromethane (3×20 ml). The combined organic layers are washed with 10% sodium hydrogen carbonate solution (30 ml), brine (30 ml), dried over sodium sulfate and concentrated in vacuo. The crude product is purified by column chromatography (silica gel, 55% ethyl acetate/dichloromethane) yielding 2-cyclopropyl-N-[(3R)-3-hydroxy-4,4-dimethyl-pentyl]-6-methyl-4-morpholin-4-yl-benzamide (example 28) (0.19 g, 0.51 mmol, 39%). [M+H]+ 375.3. [α]D25=+30.0° (c 1.0, methanol).

Provenance & Evidence