Morpholine → HCID 86699753, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 4-bromo-2-methoxy-6-methyl-benzonitrile (synthesized according to the methods described in sections a) and b) of example 10) (2.0 g, 8.85 mmol), morpholine (1.2 ml, 12.8 mmol) and caesium carbonate (3.9 g, 12.0 mmol) in toluene (75 ml) is degassed and flushed with argon for 30 min and the mixture is heated to 40° C. followed by the addition of tris(dibenzylideneacetone)-dipalladium(0) (0.37 g, 0.39 mmol) and 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (0.55 g, 0.88 mmol). The resulting mixture is stirred at 110° C. for 16 h. After completion of the reaction (monitored by TLC), the mixture is poured into water (60 ml) and extracted with ethyl acetate (3×50 ml).The combined organic layers are washed with water (2×50 ml), brine (2×30 ml), dried over sodium sulfate and concentrated in vacuo. The crude product is purified by flash column chromatography (silica gel, 25% ethyl acetate/hexane) affording 2-methoxy-6-methyl-4-morpholin-4-yl-benzonitrile (0.6 g, 2.58 mmol, 29%).

Provenance & Evidence