HCID 86699761, compound → HCID 72188142, compound

Participants

Reaction Steps

A stirred solution of N-[(4-chlorophenyl)-methyl]-2-fluoro-6-isopropenyl-4-morpholin-4-yl-benzamide (0.12 g, 0.31 mmol) in methanol (10 ml) is degassed and flushed with nitrogen before 10% palladium on carbon (25 mg) is added and the mixture is hydrogenated under hydrogen for 45 min at room temperature. After completion of the reaction (monitored by TLC), the mixture is filtered through a pad of celite and concentrated in vacuo. The resulting crude product is purified by preparative HPLC to obtain N-[(4-chlorophenyl)-methyl]-2-fluoro-6-isopropyl-4-morpholin-4-yl-benzamide (example 39) (0.04 g, 0.10 mmol, 33%). [M+H]+ 391.2.

Provenance & Evidence