反应详情

温度

100 °C

To a microwave vial was added 5-bromo-1-(cyclopropylmethyl)-3-methyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide (1-4) (0.043 g, 0.14 mmol), palladium bis(tri-tert-butylphosphine) (0.014 g, 0.027 mmol), 3-methyl-2-(tributylstannyl)pyridine (0.078 g, 0.20 mmol) and finally dioxane (1 mL). The reaction mixture was then heated under microwave irradiation at 100° C. for 10 minutes. The crude reaction mixture was then allowed to cool to room temperature, diluted with methanol, then filtered and concentrated. Purification of crude reaction mixture by reverse phase chromatography (Waters Sunfire MSC18, 10% acetonitrile/0.1% trifluoroacetic acid/water→100% acetonitrile/0.1% trifluoroacetic acid/water) to give 1-(cyclopropylmethyl)-3-methyl-5-(3-methylpyridin-2-yl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide (3-1) as a tan solid. HRMS (M+H)+: observed=330.1270, calculated=330.1271.

1. customThe crude reaction mixture
2. temperatureto cool to room temperature
3. filtrationfiltered
4. concentrationconcentrated
5. customPurification of crude
6. customreaction mixture by reverse phase chromatography (Waters Sunfire MSC18, 10% acetonitrile/0.1% trifluoroacetic acid/water→100% acetonitrile/0.1% trifluoroacetic acid/water)