N-methyl-2-pyrrolidone → HCID 68245104, compound

Participants

Reaction Steps

To a vial was added 1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-(3-piperidin-4-ylphenyl)-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide (31-3) (0.030 g, 0.064 mmol), NMP (1 mL), DIPEA (0.060 mL, 0.344 mmol), and finally methanesulfonyl chloride (0.0374 mL, 0.480 mmol). The reaction mixture was then permitted to stir at room temperature for 1 hour. The crude reaction mixture was then diluted with methanol, then filtered. Purification of crude reaction mixture by reverse phase chromatography (Waters Sunfire MSC18, 10% acetonitrile/0.1% trifluoroacetic acid/water→100% acetonitrile/0.1% trifluoroacetic acid/water) to give 1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-{3-[1-(methylsulfonyl)piperidin-4-yl]phenyl}-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide (31-4) as a tan solid. HRMS (M+H)+: observed=513.1430, calculated=513.1436.

Provenance & Evidence