1-(2-Hydroxyethyl)piperazine → Isopropyl 2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate

HRID 515255Notes

Reaction equation

HRID 515255 reaction equation
Br[C:2]1[N:7]=[C:6]([CH3:8])[N:5]=[C:4]([NH:9][C:10]2[S:11][C:12]([C:15]([O:17][CH:18]([CH3:20])[CH3:19])=[O:16])=[CH:13][N:14]=2)[CH:3]=1.[OH:21][CH2:22][CH2:23][N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1>>[OH:21][CH2:22][CH2:23][N:24]1[CH2:29][CH2:28][N:27]([C:2]2[N:7]=[C:6]([CH3:8])[N:5]=[C:4]([NH:9][C:10]3[S:11][C:12]([C:15]([O:17][CH:18]([CH3:20])[CH3:19])=[O:16])=[CH:13][N:14]=3)[CH:3]=2)[CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 49821808Isopropyl 2-(6-bromo-2-methylpyrimidin-4-ylamino)thiazole-5-formate

Product 1

HCID 49822135Isopropyl 2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formateYield 77.2%

Procedure

Prepared from isopropyl 2-(6-bromo-2-methylpyrimidin-4-ylamino)thiazole-5-formate and Compound 3: isopropyl 2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate was yielded (yield: 77.2%).

Sources & evidence

ORD record
ord-53ee88201cc24cbd94e69e6438ee6667
Source dataset
uspto-grants-2015_08
Patent number
US09108954B2

Reaction notes

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