Hydrochloric Acid → 2-(6-Bromo-2-methylpyrimidin-4-ylamino)thiazole-5-formic acid

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Reaction Steps

Methyl 2-(6-bromo-2-methylpyrimidin-4-ylamino)thiazole-5-formate (Compound 11) (32.9 g, 0.1 mol) was added into a solution of NaOH (8.0 g, 0.2 mol) in water (250 mL) prepared in advance, and reacted by stirring at room temperature overnight. After filtration the filtrate was transferred into reaction flask and pH value was adjusted to 6-6.5 with hydrochloric acid (6N) when the temperature is controlled between 20° C. and 25° C. Grew the grain by stirring for 2 h, and then filtrated and dried to give Compound 12 (21.2 g, yield: 78.3%).

Provenance & Evidence