Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,1,1,3,3,3-Hexafluoro-2-(4-((4-(4-nitrophenoxy)piperidin-1-yl)methyl)phenyl)propan-2-ol → HCID 86670926, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,1,1,3,3,3-Hexafluoro-2-(4-((4-(4-nitrophenoxy)piperidin-1-yl)methyl)phenyl)propan-2-ol | HCID 86670925 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | HCID 86670926 | HCID 86670926 | — |
반응 단계
1,1,1,3,3,3-Hexafluoro-2-(4-((4-(4-nitrophenoxy)piperidin-1-yl)methyl)phenyl)propan-2-ol (4.01 mmol, 1.92 g) and palladium (10% on carbon, Degussa) (0.040 mmol, 0.085 g) were hydrogenated in methanol (20 mL) at 5 bar for 1 hour at room temperature. The reaction mixture was filtered and the filtrate concentrated under vacuum to afford the title compound. MS (ESI) m/z 449.1 [M+H]+
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09108939B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-b21252ddc4174d2e83a820f12fa6df18 |
| 출처 메모 | uspto-grants-2015_08 |