HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 3-(4-Nitrophenoxy)pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl 3-(4-nitrophenoxy)pyrrolidine-1-carboxylate | HCID 21918683 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(4-Nitrophenoxy)pyrrolidine | HCID 21918690 | 104.2% |
Reaction Steps
tert-Butyl 3-(4-nitrophenoxy)pyrrolidine-1-carboxylate (9.73 mmol, 3 g) was dissolved in dichloromethane (2.5 mL). Trifluoroacetic acid (1 mL) was added and the reaction mixture stirred at room temperature for 30 minutes. The reaction was purified by SCX chromatography to give the title compound (2.11 g). MS (ESI) m/z 209.0 [M+H]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09108939B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-54bb31743a8643388a9fed0be0dfd105 |
| Source note | uspto-grants-2015_08 |