m-Chloroperbenzoic acid → HCID 86670938, compound

Participants

Reaction Steps

To an ice-cooled solution of 1-(4-((1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-yl)methyl)phenyl)-3-(tetrahydrothiophen-3-yl)urea (0.243 mmol, 140 mg) in dichloromethane was added 3-chloroperoxybenzoic acid (0.243 mmol, 54.5 mg) and the resulting mixture was stirred for 30 minutes. Additional 3-chloroperoxybenzoic acid (0.243 mmol, 54.5 mg) was added and reaction stirred for 1.5 hours. The reaction was concentrated under vacuum. The residue was purified by silica column chromatography (eluent: 2% methanol in dichloromethane-7% methanol in dichloromethane) and SCX chromatography to give the title compound (77.1 mg).

Provenance & Evidence