2-Amino-2-methyl-1-propanol → 2-Amino-2-methylpropyl 4-((1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-yl)methyl)phenylcarbamate

Participants

Reaction Steps

2-(4-((4-(4-Aminobenzyl)piperidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (0.448 mmol, 200 mg) and 4-nitrophenyl carbonochloridate (0.448 mmol, 90 mg) were combined and stirred in dichloromethane at room temperature for 30 minutes. 2-Amino-2-methylpropan-1-ol (0.896 mmol, 114 μl, 80 mg) was added and the reaction stirred at room temperature overnight. The reaction mixture was concentrated and purified by basic prep-HPLC to give the title compound (94.7 mg).

Provenance & Evidence