反应详情

1-Chloro-4-fluoro-2-methyl-5-nitrobenzene (1 g) was dissolved in chlorobenzene (6 mL) and N-bromosuccinimide (1.408 g) was added followed by benzoyl peroxide (0.183 mg). The reaction mixture was stirred at reflux for 4 hours. The reaction mixture was cooled and water was added. The mixture was extracted with dichloromethane (3×) and concentrated under reduced pressure. The crude oil obtained was triturated with diethyl ether, filtered and the filtrate concentrated under reduced pressure (3×) to yield the title compound (1.55 g).

1. temperatureat reflux for 4 hours
2. temperatureThe reaction mixture was cooled
3. extractionThe mixture was extracted with dichloromethane (3×)
4. concentrationconcentrated under reduced pressure
5. customThe crude oil obtained
6. customwas triturated with diethyl ether
7. filtrationfiltered
8. concentrationthe filtrate concentrated under reduced pressure (3×)